Mister Freeze suffered a lab experiment gone wrong and must now be encased in his supercooled suit to survive. Armed with his freeze gun, Victor Fries has devoted his life to the hopeless task of curing his beloved wife, Nora Fries. Her body is kept frozen in suspended animation until his experiments cure her fatal disease. Batman has offered help, but Mister Freeze is convinced his own failures are due to the meddling of the Dark Knight.
Mister Freeze often partners with other criminals to steal the money and materials he needs for his experiments and his armor and weaponry.