The saddest The Big Bang Theory moments would even get to Sheldon. Our countdown includes Sheldon says no to Amy, Professor Proton dies, Stuarts comic book store burns down, and more! Which Big Bang Theory moment hit you hard? Let us know in the comments!

Watch more great The Big Bang Theory videos here:
Top 20 Most Memorable Big Bang Theory Cameos - https://youtu.be/2MNrJYB-8dY
Top 10 Big Bang Theory Plot Holes You Didnt Notice - https://youtu.be/axjdwp5qGI0
10 Times Penny Was the Best Character on The Big Bang Theory - https://youtu.be/quzu-Bb6q4w

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